Robert Winston’s early research contributed to a new understanding of the female reproductive system and some of the diseases that affect millions of women worldwide. Through close collaborations with highly skilled researchers and surgeons, the work carried out by Winston at the reproductive group at Hammersmith Hospital, and subsequently the Institute of Reproductive and Developmental Biology, has revolutionized in vitro fertilisation (IVF) and the treatment of female reproductive diseases. Numerous overseas medical and science graduates came to train with these research groups from all over the world, and there are now alumni from the unit in about 80 different countries.
Winston’s current research activities, a collaboration between researches at the California Institute of Technology and Imperial College, London, has a genetic focus with diverse aims that include improving the production of stem cells from embryonic tissue and reducing genetic abnormalities in embryos.
Early research – Robert Winston’s early research and work in the field of female reproductive medicine led to greater understanding of reproductive diseases and improved interventions to help women around the world.
The research Robert Winston carried out early in his career on animal models led to the development of meticulous techniques to improve fertility surgery. Winston developed both the technique and instruments to carry out pelvic microsurgery, which enabled him to study various reproductive system diseases, including fallopian tube damage and pelvic inflammatory disease.
The study of the ciliated epithelium, the cells with tiny hairs that line the Fallopian tubes and help move the egg from ovaries to womb, and examination of the Fallopian tubes in close detail, allowed greater understanding of both ectopic pregnancy and hydrosalpinx. Both these conditions affect millions of women around the world.
Through contributions to treating ectopic pregnancy and developing techniques to unblock fallopian tubes, Winston developed now commonplace surgeries that have led to high pregnancy rates yet to be surpassed by modern IVF methods.
Early collaborators and the birth of modern IVF – Throughout the 1980s and 1990s, the work of the reproductive group at Hammersmith Hospital revolutionized in vitro fertilisation (IVF), leading to its place as one of the most successful units in the world.
As well as Raul Margara and Stephen Franks, many other talented individuals contributed to the early work of the Hammersmith Hospital’s reproductive group. Under the scientific leadership of Stephen Hillier, many contributions to improve infertility treatment and IVF were made and the Hammersmith IVF unit became one of the most successful in the world.
When Steve Hillier decided to move to Edinburgh to take up a professorial appointment, Alan Handyside joined the group as scientific director. Under his leadership, the group’s research investigated why many human embryos are not able to survive, and led to radical developments in the field of IVF technology.
The introduction of techniques that allowed embryo biopsies to be taken, and their genetic information to be amplified, led to the birth of the first children free of fatal gene defects were born in 1990. Further work in collaboration with Joy Delhanty, from University College, London, led to quick efficient evaluation of potential genetic abnormalities in embryos.
In 2002, a major ambition was realised when, under Winston’s leadership, the Institute of Reproductive and Developmental Biology (IRDB) was opened on the Hammersmith site, with 130 scientists and clinicians working in 12 related research groups carrying out internationally competitive research.
Current work and research – Robert Winston’s current research, in collaboration with Dr Carol Readhead, has a genetic focus, examining a wide range of areas that looks at embryo viability and the reduction of genetic abnormalities.
Whilst the IRDB was being established, Robert Winston joined forces with Dr Carol Readhead, a senior scientist from the California Institute of Technology, Pasadena. Carol is highly experienced in various aspects of genetic research, and she and Winston still work together. Currently, they supervise a group working between the IRDB and California who focus on stem cells and the production of transgenics (organisms which contain pieces of genetic information from another organism or species).
Their team, which offers opportunities for appropriate post-graduate students, includes:
Dr Feride Oeztuerk-Winder investigates techniques used to insert new genetic information into existing DNA sequences. Her long-term aim to facilitate the birth of transgenic farm animals, which has the potential to improve animal and human welfare. This work is carried out scrupulously and no animal suffering is involved. Further information of the research of Dr Oeztuerk-Winder can be found here, and her publications can be found here.
Dr Anil Chandrashekran’s research examines retroviral vectors, viruses that deliver genetic information into existing genes, into male germ stem cells, the cells that produce sperm. The development of a retrovirus that specifically targets these stem cells will make delivery more efficient and safer. Further information of the research of Dr Chandrashekran can be found here, and his publications can be found here.
Dr Ellen Poon’s research focuses on techniques for obtaining human and mouse embryonic stem cells, known as deriving stem cells, from sources such as donated embryos from IVF. This is difficult and current processes are inefficient. The chance of getting normal stem cells at the end of the process is less than five per cent, partly because most human embryos contain significant faults. One problem is that they often have cells with abnormal chromosomes so that they are not viable, but there is no easy way of detecting this at the time the embryo is donated.
Dr Sheba Jarvis is a medically qualified doctor who examines the development of male germ cells, the cells that produce sperm, and the genes they express at different stages of their life cycle. Further information of the research of Dr Jarvis can be found here and her publications can be found here.
Robert Winston’s extensive contributions to the field of reproductive medicine is catalogued through a wide range of articles, reviews, book chapters and academic educational videos dating back to 1973. His most recent publications are:
Kapustin Y, Chan E, Sarkar R, Wong F, Vorechovsky I, Winston RM, Tatusova T, Dibb NJ. Cryptic splice sites and split genes. Nucleic Acids Res. 2011 39(14):5837-5844. doi: 10.1093/nar/gkr203
Winston RM. Does government regulation inhibit embryonic stem cell research and can it be effective? Cell Stem Cell. 2007 1(1):27-34. doi: 10.1016/j.stem.2007.05.006
Lavery S, El-Shawarby SA, Moissidou M, Taylor D, Turner C, Lavender B, Trew G, Margara R, Winston R. Live birth following preimplantation genetic screening for trisomy 21. Should aneuploidy screening be offered to all older patients undergoing IVF? Hum Fertil (Camb). 2008 11(1):29-32. doi: 10.1080/14647270701541087
Carlsson IB, Laitinen MP, Scott JE, Louhio H, Tuuri T, Aaaltonen J, Ritvos O, Winston RM, Hovatta O. Kit ligand and c-Kit are expressed during early human ovarian follicular development and their interaction is required for the survival of follicles in long-term culture. Reproduction. 2006 131(4):641-9. doi: 10.1530/rep.1.00868
Jarvis S, Elliott DJ, Morgan D, Winston RML, Readhead C. Molecular markers for the assessment of postnatal male germ cell development in the mouse. Hum Reprod. 2005; 20:108-16. doi: 10.1093/humrep/deh565
Winston’s most cited publications include:
Handyside AH, Lesko JG, Tarín JJ, Winston RM, Hughes MR. Birth of a normal girl after in vitro fertilization and preimplantation diagnostic testing for cystic fibrosis. N Engl J Med. 1992. 327(13):905-9. Doi 10.1056/NEJM199209243271301
Delhanty JD, Harper JC, Ao A, Handyside AH, Winston RM. Multicolour FISH detects frequent chromosomal mosaicism and chaotic division in normal preimplantation embryos from fertile patients. Hum Genet. 1997. 99(6):755-60. Doi 10.1007/s004390050443
Hardy K, martin KL, Leese HJ, Winston RM, Handyside AH. Human preimplantation development in vitro is not adversely affected by biopsy at the 8-cell stage. Hum Reprod. 1990. 5(6):708-14.
A full list of Winston’s academic publications can be found below:
Scientific Publications in Peer-review Journals
Kapustin Y, Chan E, Sarkar R, Wong F, Vorechovsky I, Winston RM, Tatusova T, Dibb NJ. Cryptic splice sites and split genes. Nucleic Acids Res. 2011 39(14):5837-5844.
Winston RM. Does government regulation inhibit embryonic stem cell research and can it be effective? Cell Stem Cell. 2007 1(1):27-34.
Lavery S, El-Shawarby SA, Moissidou M, Taylor D, Turner C, Lavender B, Trew G, Margara R, Winston R. Live birth following preimplantation genetic screening for trisomy 21. Should aneuploidy screening be offered to all older patients undergoing IVF? Hum Fertil (Camb). 2008 11(1):29-32.
Baker JC and Winston RML Science and policy making: lessons from the UK Parliament. (submitted to Science)
Carlsson IB, Laitinen MP, Scott JE, Louhio H, Tuuri T, Aaaltonen J, Ritvos O, Winston RM, Hovatta O: Kit ligand and c-Kit are expressed during early human ovarian follicular development and their interaction is required for the survival of follicles in long-term culture. Reproduction. 2006 131(4):641-9.
Jarvis S, Elliott DJ, Morgan D, Winston RML, Readhead C. Molecular markers for the assessment of postnatal male germ cell development in the mouse. Hum Reprod. 2005; 20:108-16
Sills ES, Winston RML, Palermo GD. Journal of Experimental and Clinical Assisted Reproduction: shaping the future of research and practice in reproductive endocrinology/infertility. J Exp Clin Assist Reprod. 2004;1
Winston R. Playing god? Nature. 2003 Dec 11; 426:603.
Tachataki M, Winston RM, Taylor DM. Quantitative RT-PCR reveals tuberous sclerosis gene, TSC2, mRNA degradation following cryopreservation in the human preimplantation embryo. Mol Hum Reprod. 2003 9:593-601
Hardy K, Stark J, Winston RM. Maintenance of the inner cell mass in human blastocysts from fragmented embryos. Biol Reprod. 2003 68:1165-9.
Winston RML and Hardy K. Are we ignoring the potential dangers of in vitro fertilization and related treatments? Nature Cell Biology: 2002 Oct. 4 , S14-S19
Lavery SA, Aurell R, Turner C, Castello C, Veiga A, Barri PN, Winston RM. Preimplantation genetic diagnosis: patients’ experiences and attitudes. Hum Reprod. 2002 Sep;17:2464-7.
Spanos S, Rice S, Karagiannis P, Taylor D, Becker DL, Winston RM, Hardy K. Caspase activity and expression of cell death genes during development of human preimplantation embryos. Reproduction. 2002 Sep;124:353-63.
Abou-Sleiman PM, Apessos A, Harper JC, Serhal P, Winston RM, Delhanty JD. First application of preimplantation genetic diagnosis to neurofibromatosis type 2 (NF2). Prenat Diagn. 2002;22:519-24.
George AJ, Gale R, Korn D, Winston R. Research governance at the crossroads. Nature Medicine. 2002;8:99-101.
Makrigiannakis A, Coukos G, Mantani A, Prokopakis P, Trew G, Margara R, Winston R, White J. Expression of Wilms’ tumor suppressor gene (WT1) in human endometrium: regulation through decidual differentiation. J Clin Endocrinol Metab. 2001;86:5964-72.
Van den Broecke R, Liu J, Handyside A, Van der Elst JC, Krausz T, Dhont M, Winston RM, Hovatta O. Follicular growth in fresh and cryopreserved human ovarian cortical grafts transplanted to immunodeficient mice. Eur J Obstet Gynecol Reprod Biol. 2001;97:193-201
Horne AW, White JO, Margara RA, Williams R, Winston RM, Lalani E. MUC 1: a genetic susceptibility to infertility? Lancet. 2001;357(9265):1336-7.
Ravhon A, Lavery S, Aurell R, Trew G, Margara R, Winston R. Clinical experience with recombinant follicle-stimulating hormone (FSH) and urinary FSH: a retrospective case- controlled analysis. Fertil Steril. 2001;75:920-5.
Winston R. Embryonic stem cell research. The case for. Nature Medicine. 2001;7:396-7
Hardy K, Spanos S, Becker D, Iannelli P, Winston RM, Stark J. From cell death to embryo arrest: mathematical models of human preimplantation embryo development. Proc Natl Acad Sci U S A. 2001;98(4):1655-60.
Taylor DM, Handyside AH, Ray PF, Dibb NJ, Winston RM, Ao A. Quantitative measurement of transcript levels throughout human preimplantation development: analysis of hypoxanthine phosphoribosyl transferase. Mol Hum Reprod. 2001;7:147-54.
Hardy K, Wright CS, Franks S, Winston RM. In vitro maturation of oocytes. Br Med Bull. 2000;56:588-602
Spanos S, Becker DL, Winston RM, Hardy K. (2000) Anti-apoptotic action of insulin-like growth factor-I during human preimplantation embryo development Biol Reprod. 63:1413-20.
Ravhon A, Lavery S, Michael S, Donaldson M, Margara R, Trew G, Winston R. Dynamic assays of inhibin B and oestradiol following buserelin acetate administration as predictors of ovarian response in IVF. Hum Reprod. 2000;15:2297-301.
Ravhon A, Lawrie H, Ellenbogen A, Lavery S, Trew G, Winston R. A prospective, randomized controlled trial comparing the efficacy of recombinant follicle-stimulating hormone in three different in vitro fertilization protocols. Fertil Steril. 2000;73:908-12
Ravhon A, Aurell R, Lawrie H, Margara R, Winston RM. The significance of delayed suppression using buserelin acetate and recombinant follicle-stimulating hormone in a long protocol in vitro fertilization program. Fertil Steril. 2000;73:325-9.
Conn CM, Cozzi J, Harper JC, Winston RML, Delhanty JD (1999) Preimplantation genetic diagnosis for couples at high risk of Down syndrome pregnancy owing to parental translocation or mosaicism. J Med Genet. 36:45-50
Cozzi J, Conn CM, Harper JC, Winston RML, Rindl M, Farndon PA, Delhanty JD (1999) A trisomic germ cell line and precocious chromatid segregation leads to recurrent trisomy 21 conception. Hum Genet. 104:23-8
Ray PF, Harper JC, Ao A, Taylor DM, Winston RM, Hughes M, Handyside AH (1999) Successful preimplantation genetic diagnosis for sex-linked Lesch–Nyhan Syndrome using specific diagnosis. Prenat Diagn 19:1237-41.
Devreker F, Van den Bergh M, Biramane J, Winston RML, Englert Y, Hardy K (1999) Effects of taurine on human embryo development in vitro. Hum Reprod 14:2350-6
Wright CS, Hovatta O, Margara R, Trew G, Winston RM, Franks S, Hardy K (1999) Effects of follicle-stimulating hormone and serum substitution on the in-vitro growth of human ovarian follicles. Hum Reprod. 14:1555-62
Conn CM, Harper JC, Winston RM, Delhanty JD (1998) Infertile couples with Robertsonian translocations: preimplantation genetic analysis of embryos reveals chaotic cleavage divisions. Hum Genet;102(1):117-123
Devreker F, Winston RM, Hardy K (1998) Glutamine improves human preimplantation development in vitro. Fertil Steril;69(2):293-299
Ao A, Wells D, Handyside AH, Winston RM, Delhanty JD (1998) Preimplantation genetic diagnosis of inherited cancer:familial adenomatous polyposis coli. J Assist Reprod Genet;15(3):140-144
Conaghan J, Hardy K, Leese HJ, Winston RML, Handyside AH (1998) Culture of preimplantation embryos to the blastocyst stage: a comparison of three media. Int J Dev Biol;42:885-93
Lighten AD, Moore GE, Winston RML, Hardy K (1998) Routine addition of human insulin-like growth factor-1 ligand could benefit clinical in-vitro fertilization culture. Hum Reprod. 13:3144-50
Ray PF, Ao A, Taylor DM, Winston RML, Handyside AH (1998) Assessment of the reliability of single blastomere analysis for preimplantation diagnosis of the delta F508 deletion causing cystic fibrosis in clinical practice Prenat Diagn; 18:1402-12
Delhanty JDA, Harper J, Ao A, Handyside AH, Winston RML (1997) Multicolour FISH detects chromosomal mosaicism in normal preimplantation embryos from fertile patients. Hum Genet 99(6):755-760
Lighten AD, Hardy K, Winston RML, Moore GE (1997) IGF2 is parentally imprinted in human preimplantation embryos. Nature Genetics 2, 122-123
Lighten AD, Hardy K, Winston RML, Moore GE (1997) Expression of mRNA for the Insulin-like Growth Factors and their Receptors in Human Preimplantation Embryos. Mol Reprod Dev 47:134-9
Ray PF, Winston RML, Handyside AH (1977) XIST expression from the maternal X chromosome in human male preimplantation embryos at the blastyocyst stage. Hum Molecular Genetics 6: 1323-7.
Taylor DM, Ray PF, Ao A, Winston RM, Handyside AH (1997) Paternal transcripts for glucose-6-phosphate dehydrogenase and adenosine deaminase are first detectable in the human preimplantation embryo at the three- to four-cell stage.Mol Reprod Dev;48(4):442-448
Soussis I; Harper J C; Kontogianni E; Paraschos T; Packham D; Handyside AH; Winston R M L (1996) Pregnancies resulting from embryos biopsied for preimplantation diagnosis of genetic disease: Biochemical and ultrasonic studies in the first trimester of pregnancy. J Assisted Reprod Genetics 13, 254-258.
Ao A; Handyside A; Winston RML (1996) Preimplantation genetic diagnosis of cystic fibrosis (delta F508). Eur J Obstet Gynecol Reprod Biol. 65(1): 7-10
Kaeda JS, Ray PF, Bingham J, Vulliamy T, Dokal I, Roberts IA, Winston RML, Handyside A (1966) Preimplantation genetic diagnosis of Beta-Thalassaemia Major – Accurate identification of mutations following single cell amplification. Br J Haematol. 93, 198
Ray PF; Winston RM; Handyside AH (1996) Reduced allele dropout in single-cell analysis for preimplantation genetic diagnosis of cystic fibrosis. J Assist Reprod Genet. 13(2): 104-6
Ao A; Ray P; Harper J; Lesko J; Paraschos T; Atkinson G; Soussis I; Taylor D; Handyside A; Hughes M; Winston RML (1996) Clinical experience with preimplantation genetic diagnosis of cystic fibrosis (delta F508). Prenat Diagn. 16(2): 137-42
Soussis I; Harper JC; Handyside AH; Winston RML (1996) Obstetric outcome of pregnancies resulting from embryos biopsied for pre-implantation diagnosis of inherited disease. Br J Obstet Gynaecol. 1996; 103(8): 784-8
Hardy K, Warner A, Winston RM, Becker DL. (1996) Expression of intercellular junctions during preimplantation development of the human embryo. Molecular Hum Reprod. 2: 621-326.
Nikas G, Ao A, Winston RML, Handyside AH (1996) Compaction and surface polarity of the human embryo in vitro. Biol Reprod.55,32-37
Chia M, Winston RML, Handyside AH (1995) TI: EGF, TGF-alpha and EGFR expression in human preimplantation embryos. Development. 121(2): 299-307
Ray PF; Conaghan J; Winston RM; Handyside AH (1995) Increased number of cells and metabolic activity in male human preimplantation embryos following in vitro fertilization. J Reprod Fertil. 104: 165-71
Harper JC; Coonen E; Handyside AH; Winston RML; Hopman AH; Delhanty JD (1995) Mosaicism of autosomes and sex chromosomes in morphologically normal, monospermic preimplantation human embryos. Prenat Diagn 15, 41-9
Hardy K; Robinson FM; Paraschos T; Wicks R; Franks S; Winston RML (1995) Normal development and metabolic activity of preimplantation embryos in vitro from patients with polycystic ovaries. Hum Reprod 10(8): 2125-35
Geber S, Handyside AH, Winston RML (1995) Proliferation of blastomeres from biopsied cleavage stage human embryos in vitro: an alternative to blastocyst biopsy for preimplantation diagnosis. Hum Reprod 10(6): 1492-6
Delhanty JDA, Ao A, Wells D, Handyside AH, Winston RML (1995) Single cell analysis of the APC gene for preimplantation genetic diagnosis of familial adenomatous polyposis coli. Am J Hum Genet. 57, 1614.
Conn CM, Harper JC, Winston RML, Delhanty JDA (1995) Preimplantation diagnosis for trisomy 13, trisomy 14, trisomy 18, and trisomy 21 in translocation carriers using multicolor fluorescent in situ hybridization Am J Hum Genet. 57, 1611
Harper J C; Dawson K; Delhanty J A; Winston R M L (1995) The use of fluorescent in-situ hybridization (FISH) for the analysis of in-vitro fertilization embryos: A diagnostic tool for the infertile couple. Hum Reprod 10 (12) 3255-3258.
Delhanty JD, Handyside AH, Winston RML, Hughes M (1994) Sex determination of preimplantation embryos. Lancet 343, 549
Harper JC, Coonen E, Ramaekers FCS, Delhanty JDA, Handyside AH, Winston RML, Hopman AHN (1994) Identification of the sex of human preimplantation embryos in two hours using an improved spreading method and fluorescent in-situ hybridization (FISH) using directly labelled probes. Hum Reprod 9, 721-4
Delhanty JD; Handyside AH; Winston RML (1994) Preimplantation diagnosis. Lancet. 343(8912): 1569-70
Griffin DK, Handyside AH, Harper JC, Wilton LJ, Atkinson GA, Soussis J, Ao A, Delhanty JDA, Winston RML (1994) Clinical experience with preimplantation diagnosis of sex by fluorescent in siru hybridization. J Ass Rep Gen, 11, 3, 141-51
Harper JC; Robinson F; Duffy S; Griffin DK; Handyside AH; Delhanty JD; Winston RM (1994) Detection of fertilization in embryos with accelerated cleavage by fluorescent in-situ hybridization (FISH). Hum Reprod 9, 1733-7
Winston RML (1994) Limitations to human germ-line gene therapy. Politics and the Life Sciences, 13, 237-9.
Ao A, Erickson RP, Winston RML, Handyside AH (1994) Transcription of paternal Y-linked genes in the human zygote as early as the pronucleate stage. Zygote. 2(4): 281-7
Schrurs BM, Winston RML, Handyside AH (1993) Preimplantation diagnosis of aneuploidy using fluorescent in-situ hybridization: evaluation using a chromosome 18-specific probe. Hum Reprod 8, 296-301
Tarin JJ, Conaghan J, Winston RML, Handyside AH (1993) Human embryo biopsy on the 2nd day after insemination for preimplantation diagnosis: removal of a quarter of the embryo retards cleavage. Fertil Steril 58, 970-6
Griffin DK, Wilton LJ, Handyside AH, Atkinson GH, Winston RML, Delhanty JD (1993) Diagnosis of sex in preimplantation embryos by fluorescent in situ hybridisation. BMJ 306, 1382
Conaghan J, Hardy K, Handyside AH, Winston RML, Leese HJ (1993) Selection criteria for human embryo transfer: a comparison of pyruvate uptake and morphology J Assist Reprod Genet 10, 21-30
Winston RML, Handyside AH (1993) New Challenges in human in vitro fertilization. Science 260, 932-6
Conaghan J, Handyside AH, Winston RML, Leese HJ (1993) Effects of pyruvate and glucose on the development of human preimplantation embryos in vitro. J Reprod Fertil 99, 87-95
Martin KL, Hardy K, Winston RML, Leese HJ (1993) Activity of enzymes of energy metabolism in single human preimplantation embryos. J Reprod Fertil 99, 259-66
Hardy K, Winston RML, Handyside AH (1993) Binucleate blastomeres in preimplantation human embryos in vitro: failure of cytokinesis during early cleavage. J Reprod Fertil 98, 549-58
Delhanty JD, Griffin DK, Handyside AH, Harper J, Atkinson GH, Pieters MH, Winston RML (1993) Detection of aneuploidy and chromosomal abnormality in embryos Hum Reprod 8, 1696-700
Griffin DK, Wilton LJ, Handyside AH, Winston RML, Delhanty JDA (1992) Dual fluorescent in situ hybridisation for simultaneous detection of X-chromosome-specific and Y-chromosome-specific probes for the sexing of human preimplantation embryonic nuclei. Hum Genet. 89, 18-24.
Conaghan J, Hardy K, Winston RML, Leese HJ (1992) Pyruvate uptake in relation to pregnancy outcome after human IVF. J. Reprod Fertil, 27, 39
Handyside AH; Lesko JG; Tarin JJ; Winston RM; Hughes MR (1992) Birth of a normal girl after in vitro fertilization and preimplantation diagnostic testing for cystic fibrosis N Engl J Med, 327 (13) 905-9.
Conaghan J, Handyside AH, Winston RML, Leese HJ. (1992) Glucose inhibits cleavage of human preimplantation embryos in vitro. J Reprod Fertil, 10, 4.
Geber S, Winston RML, Handyside AH (1992) Blastomeres isolated by cleavage stage biopsy of human embryos form trophectoderm vesicles in vitro. J Reprod Fertil.10, 51
Handyside AH, Harper J, Winston RML (1992) Preliminary evaluation of the use of in vitro fertilisation for preimplantation diagnosis of inherited disease. J Reprod Fertil. 10, 53
Winston RML, Handyside AH, Hardy K (1992) BABI in dispute. Nat Genet, 1, 320
Leese HJ; Humpherson PG; Hardy K; Hooper MA; Winston RM; Handyside AH (1991) Profiles of hypoxanthine guanine phosphoribosyl transferase and adenine phosphoribosyl transferase activities measured in single preimplantation human embryos by high-performance liquid chromatography. J Reprod Fertil, 91 (1)197-202
Gott AL, Hardy KL, Winston RML, Leese HJ (1990) Non-invasive measurement of pyruvate and glucose uptake and lactate production by single human preimplantation embryos. Human Reprod. 5, 104.
Soussis I, Jeer H, Packham C, Margara RA, Handyside AH, Winston RML (1991) Ultrasonic and biochemical parameters of early pregnancies following transfer of biopsied human embryos for X-linked genetic disorders. Hum Reprod 6, 138.
Griffin DK, Handyside AH, Penketh RJA, Winston RML, Delhanty JDA (1991) Fluorescent in situ hybrididsation to interphase nuclei of human preimplantation embryos with X and Y chromosome specific probes. Human Reprod. 6, 101-105.
Hardy K, Winston RML, Handyside AH (1991) Nuclear abnormalities and developmental arrest in human preimplantation embryos in vitro. Hum Reprod 6, 152
Griffin DK, Delhanty JDA, Handyside AH, Winston RML (1991) Preimplantation diagnosis for sex-linked disorders using fluorescent in situ hybridisation Clin. Genetics
Conaghan J, Martin K, Hardy K, Winston NJ, Dawson KJ, Winston RML (1991) Prospects for pre-transfer assessment of human embryo viability following in vitro fertilization. Hum Reprod 6, 232
Winston RML, Soussis J, Dawson K, Handyside AH (1991) The relevance of preimplantation diagnosis for genetic defects. Hum Reprod 6, 281.
Hardy KL, Leese HJ, Martin KL, Handyside AH, Winston RML.(1990) Human preimplantation development after biopsy at the 8-cell stage. J. Reprod. Fertil. 49, 87.
Hardy KL, Winston RML, Handyside AH.(1990) Binucleate cells in human preimplantation embryos in vitro: failure of cytokinesis during early cleavage. J Reprod Fertil 24, 38
Handyside AH, Kontogianni EH, Hardy K, Winston RML (1990) Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification. Nature, 344, 768.
Gott AL, Hardy K, Winston RML, Leese HJ (1990) The nutrition and environment of the early human embryo. Proc. Nutr. Soc. 49 (1) 2A.
Hardy KL, Leese HJ, Martin KL, Winston RML, Handyside AH,.(1990) Human preimplantation development in vitro is not adversely affected by biopsy at the 8-cell stage. Human Reprod. 5, 708-14.
Handyside AH, Hardy K, Penketh RJA, Hooper MAK, Humpherson P, Leese HJ, Winston RML: (1989) Preimplantation diagnosis of Lesch-Nyhan Syndrome. Hum. Reprod. 3 (suppl), 44.
Hardy K, Hooper MAK, Handyside AH, Winston RML, Leese HJ. (1989) Non-invasive measurement of glucose and pyruvic acid uptake by individual human pre-embryos. Hum. Reprod. 4, 188-91.
A.H. Handyside, J.K. Pattinson, R.J.A. Penketh, J.D.A. Delhanty, E.D.G. Tuddenham, RML Winston. (1989), ii, 347-9.
Penketh RJA, Delhanty JDA, Finkelstone EM, Handyside AH, Malcolm S, Winston RML.(1989) Rapid sexing of human embryos by non radioactive in situ hybridisation. Proc. Eur Soc Hum. Rep. 1,132.
Charles Coutelle, Carolyn Williams, Alan Handyside, Kate Hardy, Robert Winston, Robert Williamson.( 1989) Genetic analysis of DNA from single human oocytes: a model for preimplantation diagnosis. Brit Med. J., 299, 22-5,
Winston RML, Handyside AH, Penketh R. (1989) Embryo biopsy. Lancet, i, 1323.
Penketh RJA, Delhanty JDA, van den Berghe JA, Finkelstone EM, Handyside AH, Malcolm S, Winston RML. (1989) Rapid sexing of human embryos by non-radioactive in situ hybridisation: potential for preimplantation diagnosis of X-linked disorders. Prenatal diagnosis,9, 489-500.
Polson DW, Mason HD, Kiddy DS, Winston RML, Margara RA, Franks S. (1989)Low dose FSH in the treatment of polycystic ovarian syndrome. A comparison of pulsaltile subcutaneous with daily intra-muscular therapy. Brit. lucose uptake and lactate production by single human preimplantation embryos. Human Reproduction, 5, 1
Hardy KL, Handyside AH, Winston RML (1989) The human blastocyst: Cell number, death and allocation during late preimplantation development in vitro. Development, 107, 597.
In vitro fertilisation:
Winston R.M.L. Test tube babies: The ethical dimension. Nursing Times, 80, 29, 20-21, 1984.
Winston R.M.L., Margara R.A. and Hillier S.G. Tubal microsurgery and in vitro fertilization. Clin. Reprod. Fertil. 3, 153-4, 1985.
Dawson K.J., Hillier S.G., Wickings E.J., Margara R.A., Winston R.M.L. Embryo development and quality control in in vitro fertilization. In In Vitro Fertilization and Donor Insemination. Edited by W. Thompson, D.N. Joyce, J.R. Newton. Royal College of Obstetricians and Gynaecologists, London, 1985. 125-137
Winston RML, Margara RA, Hanna L, Hillier SG. Preparation of the pelvis for in vitro fertilization. In In Vitro Fertilization and Donor Insemination. Ed. W Thompson, D.N. Joyce, J.R. Newton. RCOG London, 1985. 173-182
Winston R.M.L. and Hillier S.G. I.V.F. versus nature. Lancet i, 284, 1985.
Hillier S.G., Winston R.M.L., Margara R.A., Afnan M.A. Superovulation strategy before vitro fertilization treatment cycles. Clin. Obstet. Gynaec. 12, 687-723, 1985.
Winston, R.M.L. and Hillier, S.G. The interface between tubal surgery and in vitro fertilization. Clin. Obstet. Gynaecol. 1986.
Golan A, Dargenio R, Winston RML. Effect of treatment of experimentally produced endometrial peritoneal implants. Fertil. Steril., 46, 954-8. 1986.
Winston R.M.L. and Margara R.A. Effectiveness of treatment for infertility. Br. Med. J., 295, 608, 1987.
Winston RML, Margara RA. Clinical algorhythms: infertility. Br. Med. J. 294, 1230, 1987.
Otubu JA, Winston RML. Spontaneous contractile pattern of isolated circular and longitudinal muscle layers from ampullae of normal and damaged fallopian tubes. Afr. J. Med. med Sci.16(1), 33-7, 1987.
Winston R.M.L. Why a ban on embryo research would be a tragedy. Brit Med J. 295, 1501-2, 1987.
Winston RML, Margara R.A., Dawson K., Hillier S.G. In vitro fertilization in a health service hospital. Vth World Congress on In Vitro Fertilization and Embryo Transfer. Abstract Book, American Fertility Society, AP-679, 174.
K Dawson, RA Margara, SG Hillier, N Winston, D Packham, RML Winston. Factors affecting success at the time of embryo transfer. Vth World Congress on In Vitro Fertilization and Embryo Transfer, American Fertility Society, AP-680, 175.
Rutherford AR, Subak-Sharpe RJ, Dawson KJ, Margara RA, Franks S, Winston RML.Improvement of in vitro fertilisation after treatment with buserelin, an agonist of luteinising hormone releasing hormone. Brit. Med. J. 296, 1765-8. 1988.
Rutherford AR, Subak-Sharpe RJ, Dawson KJ, Winston N, Margara RA, Franks S, Winston RML. Programmed IVF treatment using Buserelin/hMG for superovulation. Hum. Reprod. 1988; 3, 58.
Dawson KJ, Rutherford AJ, Winston NJ, Subak-Sharpe R, Winston RML. (1988) Human blastocyst transfer; is it a feasible proposition? Hum. Reprod., 3 44-5.
Conaghan J, Dimitry E, Mills M, Margara RA, Winston RML, (1989) Delayed hCG administration for in vitro fertilization. Lancet, , ii, 1323-1324.
Dimitry ES, Oskarsson T, Mills M, Margara RA, Winston RML. (1989) Combined intrauterine and cervical pregnancy from in vitro fertilization and embryo transfer. Fertil Steril. 52, 874-5,.
Golombok S., Bhanji F., Rutherford AR, Winston RML. (1990) Psychological development of children of the new reproductive technologies: Issues and a pilot study of children conceived by IVF. J. Inf. Reprod. Psychol. 27, 203.
Rizk B, Dimitry ES, Morcos S, Edwards RG, Brinsden P, Winston RML (1990) A multicentre study on combined intrauterine and extrauterine pregnancy after IVF. Hum Reprod 5, 113-4
Dimitry ES, Subak-Sharpe R, Mills M, Margara RA, Winston RML (1990) Nine cases of heterotopic pregnancies in four years of in vitro fertilization. Fertil. Steril. 53, 107.
Mastrominas M, Dimitry ES, Packham D, Margara RA, Winston RML (1991) The relation between duration of Buserelin administration and IVF outcome. J Reprod Fertil 30, 50
Dimitry ES, Bates SA, Oskarsson T, Margara RA, Winston RML (1991) Programming IVF for a 5 or 3 day week. Fertil Steril 55, 934-938.
Dimitry ES; Oskarsson T; Margara R; Winston RM (1990) Heterotopic pregnancy associated with assisted reproductive technology. Am J Obstet Gynecol 163, 244-5.
Perks NF, Sherriff EA, Winston RML (1991) Normal early pregnancy: Serum hCG levels and vaginal ultrasonography findings. Br J Obstet Gynaecol 98, 330-31.
Winston RML (1991) In vitro fertilization or tubal surgery? Lancet ii, 337, 1096.
Oskarsson T, Dimitry ES, Mills MS, Hunt J, Winston RML (1991) Attitudes towards gamete donation among couples undergoing in vitro fertilization. Br J Obstet Gynaecol 98, 351-6.
Dawson KJ, Perks NF, Sherriff EA, Margara RA, Winston RML. (1991) Limiting multiple pregnancies without reducing success with in vitro fertilization. J Obstet Gynaecol. 11, 163.
Dawson KJ; Rutherford AJ; Margara RA; Winston RML (1991) Reducing triplet pregnancies following in-vitro fertilisation. Lancet 337 (8756) p1543-4
Bates SA, Hall V, Soussis I Margara RA, Winston RML (1991) Age 40 to 45: outcome of in vitro fertilization at Hammersmith. Hum Reprod 6, 175
Winston RML (1991) The Cook Report: assisted conception. Brit Med J 302 (6786) 1204
Soussis I; Dimitry ES; Oskarsson T; Margara R; Winston R (1991)Diagnosis of ectopic pregnancy by vaginal ultrasonography with a discriminatory serum hCG level of 1000 IU/l (IRP) Br J Obstet Gynaecol 98: 233
Packham C, Dawson KJ, Margara RA, Winston RML (1991) Levels of hCG in early pregnancy following IVF and embryo transfer. Hum Reprod 6, 413-6
Dimitry ES, Oskarsson T, Conaghan J, Margara RA, Winston RML (1991) Beneficial effect of a 24 hr delay in hCG administration during invitro fertilization treatment cycles. Hum Reprod 6, 922-4.
Soussis J, Bates S, Hall V, Dimitry ES, Margara RA, Winston RML (1991) Symptoms following day case IVF. Hum Reprod 6, 256.
Dawson KJ, Conaghan J, Ostera GR, Hardy K, Winston RML (1992) Pregnancy rates after IVF are similar whether embryos are transferred on day 2 or day 3 post insemination. J Reprod Fertil 10, 37
Winston RML, Dawson KJ, Margara RA, Duffy S (1992) Age and IVF outcome.J Reprod Fertil. 10, 44
Chieng HT, Winston RML, Margara RA, Lindsay KS. (1992) A simple method of Manual Zona Cracking (MZC) to assist fertilisation. J Reprod Fertil. 10, 47
Winston RML (1992) Tubal surgery or in vitro fertilization? J Assist Reprod Genet 9, 309-11
McCully B, Kent A, Winston RML, Donaldson A (1992) Excretion of hCG in early pregnancy. J Reprod Fertil. 10, 76
Geber S, Atkinson G, Margara RA, Winston RML (1992) Results of IVF in patients with endometriosis: The severity of disease does not affect outcome nor incidence of miscarriages. J Reprod Fertil.10, 106
Baker G, Brinsden P, Jouannet P, Loumaye E, Van Steirteghem A, Winston R (1993) Treatment of severe male infertility with pure follicle-stimulating hormone (FSH): the need for a properly controlled multicentred trial. Hum Reprod 8, 500-1
Atkinson G, Apperley J, Dawson K, Goldman J, Winston RML (1994) Successful pregnancy after allogeneic bone marrow transplantation for chronic myeloid leukaemia. Lancet 344, 199
Geber S, Margara R, Winston RML (1995) Results of in vitro fertilization for the treatment of patients with endometriosis. Jornal Brasileiro de Ginecologia, 105, 163-168
Dawson KJ; Conaghan J; Ostera GR; Winston RML; Hardy K (1995) Delaying transfer to the third day post-insemination, to select non-arrested embryos, increases development to the fetal heart stage. Hum Reprod 10, 177-82
Fountain SA; Morrison JJ; Smith SK; Winston RML (1995) Ultrasonographic growth measurements in triplet pregnancies. J Perinat Med. 23(4): 257-63
Geber S; Paraschos T; Atkinson G; Margara R; Winston RM (1995) Results of IVF in patients with endometriosis: the severity of the disease does not affect outcome, or the incidence of miscarriage. Hum Reprod. 10(6): 1507-11
Soussis I, Trew G, Matalliotakis I, Winston RML (1996) Symptoms after day-case in vitro fertilization. J Ass Reprod Gen 13, 513-516
Bevan RK; Winston RM (1996) Assessing the costs of assisted reproductive techniques. Br J Obstet Gynaecol. 103(10): 1049-50
Hovatta O; Silye R; Krausz T; Abir R; Margara R; Trew G; Lass A; Winston RM (1996) Cryopreservation of human ovarian tissue using dimethylsulphoxide and propanediol-sucrose as cryoprotectants. Hum Reprod. 11: 1268-72
Winston RML (1996) Widows fight for husband’s sperm – Intervention by BMA Ethics Committee was ill-judged. Br Med J: 313, 1477
Lass A, Paul M, Margara RA, Winston RML (1997) Women with one ovary have a decreased response to GnRHa/HMG ovulation induction protocol in IVF but the same pregnancy rate as women with two ovaries. Hum Reprod. 12, 298-300
Hovatta O, Silye R, Abir R, Krausz T, Winston RML (1997) Extracellular matrix improves survival of both stored and fresh human primordial and primary ovarian follicles in long-term culture. Hum Reprod 12, 1032-6
Lass A, Croucher C, Lawrie H, Margara R, Winston RM. (1997) Right or left ovary–which one is better? Human Reprod 12(8):1730-1731
Abir R, Franks S, Mobberley MA, Moore PA, Margara RA, Winston RM (1997) Mechanical isolation and in vitro growth of preantral and small antral human follicles. Fertil Steril 68(4):682-688
Croucher CA, Lass A, Margara R, Winston RM (1998) Predictive value of the results of a first in-vitro fertilization cycle on the outcome of subsequent cycles. Hum Reprod;13(2):403-408
Lavery S, Lawrie H, Trew G, Winston R (1998) Age and basal follicle stimulating hormone as predictors of in vitro fertilisation outcome. Br J Obstet Gynaecol;105(7):810
Winston RML (1998) League tables of in vitro fertilisation clinics misinform patients. (1998) Brit Med J; 317:1593-4
Lass A, Ellenbogen A, Croucher C., Trew G, Margara R, Beccatini C, Winston RML (1998) Effect of salpingectomy on ovarian response to superovulation in an in vitro fertilisation – embryo transfer program. Fertil Steril 70 (6), 1035-8
Lass A, Croucher C, Duffy S, Dawson K, Margara R, Winston RML (1998) One thousand initiated cycles of in vitro fertilization in women ≥40 years of age. Fertil Steril 70, 1030-4
Soussis I, Trew G, Matalliotakis I, Margara R, Winston RM (1998) In vitro fertilization treatment in genital tuberculosis. J Assist Reprod Genet. 15:378-80.
Ravhon A, Lavery S, Trew G, Margara RA, Winston RML (1999) Predictive value of serum estradiol levels for IVF pregnancy outcome after gonadotropin stimulation. Fertil Steril 71:183-4
Nikolaou DS, Winston RML. Sporadic Perrault syndrome. J Obstet Gynaecol. 1999 19(4):436-7.
Hovatta O, Wright C, Krausz T, Hardy K, Winston RML (1999) Human primordial, primary and secondary ovarian follicles in long-term culture: effect of partial isolation. Hum Reprod. 14:2519-24.
Lavery SA, Aurell R, Turner C, Taylor DM, Winston RML (2000) An analysis of the demand for and cost of preimplantation genetic diagnosis in the United Kingdom. Prenat Diagn. 19:1205-8
Physiology and microsurgery of Fallopian tube:
Winston RML and McClure Browne, J.C. Pregnancy following autograft transplantation of the fallopian tube and ovary in the rabbit. Lancet 11:494, 1974.
Winston RML Microsurgical reconstruction of the Fallopian tube. In: Biological and Clinical Aspects of Reproduction, Proceedings of the VIIIth World Congress of Fertility and Sterility, Buenos Aires, 1974. Excerpta Medica, Congress series No. 394.
Winston RML (1975) Tube transplants. Brit. Med. J. I: 230, 1975.
Winston RML (1975) Microsurgical reanastomosis of the rabbit Fallopian tube and its functional and pathological sequelae. Brit. J. Obstet. Gynaecol. 82:513.
Winston RML (1975) Homograft and autograft transplantation of the rabbit Fallopian tube. Fertil. Steril. 26:2.
Winston RML (1975) Transplanting Fallopian tubes, in-vitro fertilization and embryo transfer. Ob-Gyn, collected letters XVI:93.
Winston RML and Gomel, V. (1976) A comparative study on the suppression of peritoneal adhesion formation in the rat. Reproduccion 2(394):321.
Winston RML (1977) Microsurgical tubo-cornual anastomosis for reversal of sterilization. Lancet I:284.
Winston RML Tubocornual anastomosis for reversal of diathermy sterilization. Lancet I:606, 1977 (Letter).
Winston RML, Frantzen, C., and Oberti, C. (1977) Oviduct function following resection of the ampullary-isthmic junction. Fertil. Steril. 28:284.
Winston RML (1977) Evaluation of the results of tuboplasty. Fertil. Steril. 28:1264
Winston RML (1977) Why 103 women requested reversal of sterilization. Brit Med J. 2:305.
Brosens, I., Oberti, C., Vasquez, G., Boeckx, W. and Winston RML, (1977) Ciliated surface of the oviduct in fertility and infertility: light optical and scanning electron microscopical study. In: Infection et Fécondité, Henry-Suchet, J. (Ed.), Paris, Masson, pps. 331.
Winston RML Reversal of sterilization: Microsurgery of the Fallopian Tube. In: Reversibility of Sterilization. Sciarra, J.J., Zatuchni, G.I., and Spiedel, J.J. (Eds.), Harper and Row, New York. 184-194 and 216-217, 1978.
Brosens, I.A., Boeckx, W., Vasquez, G., and Winston RML Implantation Intra et Extra-uterine après Microchirurgie Tubaire in l’Implantation del’Oeuf. Masson, Paris. 285, 1978.
Winston RML The future of microsurgery in infertility. Clin Obstet Gynaecol 5(3):607, 1978.
Winston RML Present status of female sterilization reversal. Med Bull., I.P.P.F. 12:1, 1978.
Winston RML Tubal anastomosis for reversal of sterilization in 45 women. In: Reversibility of Female Sterilization, Brosens, I and Winston, RML, London, Academic Press. 44, 1978.
Boeckx, W.D., Winston RML, Vasquez, G., and Brosens, I.A. Etude Clinico/Experimentale des differents segments tubaire après modifications microchirurgicales. In: Oviducte et Fertilité. Masson, Paris, pp. 139-153, 1979.
Winston RML and Brosens, I.A. Notres experience avec désterilization chez la femme. In: Oviducte et Fertilité. Masson, Paris, pp.413-421, 1979.
Vasquez, G., Winston RML, Brosens, I.A., and Boeckx, W. Anatomie fonctionelle de la trompe de Fallope. In: Oviducte et Fertilité. Masson, Paris. pp. 101-125, 1979.
Brosens, I.A., Boeckx, W., Vasquez, G., and Winston RML Selection des Candidates pour la Plastie Tubaire. In: Oviducte et Fertilite. Masson, Paris, pp. 367-377, 1979.
Winston RML Microsurgery of the Fallopian tube. (1980) From fantasy to reality. Fertil.Steril. 34: 521.
Vasquez, G., Winston RML, Boeckx, W., and Brosens, I.A. (1980) Ultrastructural changes in the tube following female sterilization. Am. J. Obstet. Gynecol. 138:86.
Winston RML (1980) Atraumatic conservative pelvic surgery. In: Microsurgery in Female Infertility. Crosignani, P.G. and Rubin, B. (Eds.), Academic Press, London, pp. 121-125.
Winston RML and Margara, R.A. Technique for the improvement of microsurgical tubal anastomosis. In: Microsurgery in Female Infertility. Crosignani, P.G. and Rubin, B. (Eds.), Academic Press, London, pp. 25-34, 1980.
Vasquez, G., Boeckx, W., Winston RML and Brosens, I.A. Human tubal mucosa and reconstructive microsurgery. In Microsurgery in Female Infertility. Academic Press, London. 41-57, 1980
Hedon, B., Wineman, M., Winston RML. (1980) Loupes or microscopes for tubal surgery. Fertil. Steril. 34:264.
Winston RML (1980) Evaluating instrumentation for gynecologic microsurgery. Contemp.Ob-Gyn. 15:153.
Koninckx, P.R., Boeckx, W., Verhoeven, H.C., Winston RML and Brosens, I.A. (1980) Impairment of ovarian ovulatory function after tubal surgery in the rabbit. Infertility, 3:85.
Hedon, B., and Winston RML Les moyens de grossissement optique en microchirurgie gynécologique. (1980) Rev. franc Gynéc. 75: 12, 705-707.
Vasquez, G., Winston RML, Boeckx, W., Gordts, S., Brosens, I.A., (1980) La muqueuse tubaire dans L’hydrosalpinx et la stérilisation. Rev. franc. Gynec. 75:12, 715-718.
Winston RML, Microcirugia en Ginecologia in Proceedings of XVIII Chilean Congress of Obstetrics and Gynaecology, edited by M. Ramon Rubio, Santiago, 1980. Bk I, 45-48.
Boeckx, W., Gordts, S., Brosens, I.A., Winston RML (1980) The use of a silicone workbench in gynecological microsurgery. Int. J. Microsurgery, 2, 101-2.
Winston, RML (1981) Controlled studies comparing microscope or loupes. Fertil.Steril. 35:98.
Hedon, B., Viala, J.L., Durand, G. et Winston, R.M.L (1981). Techniques de correction de la disparité luminale dans les anastomoses tubo-tubaires. Rev. fr. Gynécol. Obstet. 76:1, 45-49
Beyth, Y. and Winston RML (1981) Ovum capture and fertility following microsurgical fimbriectomy in the rabbit. Fertil. Steril. 35: 464.
Vasquez, G., Boeckx, W., Winston RML, and Brosens, I.A. (1981) Development of hydrosalpinges in an animal model. Fertil. Steril. 35: 342
Beyth, Y., Margara, R.A. and Winston RML (1981) Transperitoneal migration of the ovum. In Proc. IIIrd World Congress Human Reproduction, Berlin, 342
Winston, R.M.L.: Reconstructive microsurgery to the lateral end of the Fallopian tube. In: Tubal Infertility. Chamberlain, G.V.P. and Winston, R.M.L. (Eds), Blackwells, London, 1981.
Winston, R.M.L.: Is microsurgery necessary for salpingostomy? Aust NZ J Obstet Gynaecol. 21, 143-152, 1981.
Winston RML Progress in tubal surgery. Clin. Obstet. Gynaecol. 8, 653-679, 1981.
Beyth, Y. and Winston RML Ovum transport after removal of tubal circular muscle. Proc. Soc. for Gynecologic Investigation, 1982, 100.
Winston, R.M.L. Microsurgery for tubal and ovarian disease. Ann Chir. Gynaecol. 71, 97-102, 1982.
G. Vasquez, I.A. Brosens, S. Gordts, W. Boeckx and RML Winston. The Fallopian tube in infertility, in Atlas of Human Reproduction by Electron Microscopy. Edited by ESE Hafez and P. Kenemans, Raven Press, p119-128, 1983.
Vasquez G., Winston R.M.L., and Brosens I.A. Tubal mucosa and ectopic pregnancy. Brit. J. Obstet. Gynaecol. 90, 468-474, 1983.
Winston, R.M.L. and Margara, R.A. Conservative surgical management of ectopic pregnancy. J. Obstet. Gynaecol., 5, suppl 1, 1-4, 1984.
Hawkins D.F. and Winston RML Inflammatory disease of the Fallopian tube. J. Obstet. Gynaecol. 5, 198, 1985.
Beyth Y., Margara R.A. and Winston R.M.L. Transperitoneal migration and ovum capture in rabbits. Isr. J. Med Sci. 21: 514-6, 1985.
Otubu JAM and Winston RML. Ovarian function after salpingostomy, following mechanically produced hydrosalpinges in rabbits. Afr J. Med and med Sci. 15: 13-7. 1986
Otubu JAM and Winston, R.M.L. Ovarian function after salpingotomy in rabbits. Afr. J. Med med Sci. 15: 19-24., 1986.
Otubu JA, Winston RML, Wineman M, Ryder T. Morphology of human and experimental hydrosalpinges: a comparative study. Afr. J. Med med Sci., 16, 79- 88, 1987.
Brewis IA, Winston RML and Leese HJ. The energy metabolism of the human fallopian tube; effect of glucose on oxygen uptake by mucosal tissue in vitro. J. Reprod. Fertil. 58, 105, 1990
Winston RML, Margara RA (1991) Microsurgical salpingostomy is not an obsolete procedure. Br J Obstet Gynaecol 98, 637-642.
Brewis IA, Winston RML, Leese HJ (1992) Energy metabolism of the human fallopian tube. J Reprod Fert. 95, 257-62.
Dimitry ES, Soussis I, Oskarsson T, Margara RA, Winston RML (1992) The use of transvaginal ultrasound in the diagnosis of ectopic pregnancy. J Obstet Gynecol 12, 258-61
The ovary and ovulation:
Balmeceda, J.P., Eddy, C.A., Winston RML and Asch, R.H. Perfusion of the Rhesus monkey ovary. Studies in corpus luteum function. Fertil. Steril. 37, 309-310, 1982.
Hillier S.G., Parsons J.H., Margara R.A., Crofton M.E. and Winston R.M.L., Pre-ovulatory follicular function in in vitro fertilization (IVF) patients, U.S. Endocrine Society Annual Meeting, San Antonio, Texas. Endocrinology 112 (Suppl), 905, 1983.
Winston R.M.L., Margara R.A., Hillier S.G. Technique and results of ovariolysis in preparation for in vitro fertilization. Europ. J. Obstet Gynaec., 18, 381-90, 1984.
Otubu, J.A.M., Winston RML Ovarian function after salpingostomy in mechanically-induced hydrosalpinges in rabbits. Fertil. Steril. 41: 11, 1984.
Hillier, S.G., Parsons, J.H., Margara, R.A., Winston, R.M.L. Serum estradiol and preovulatory follicular development before in vitro fertilization. J. Endocr. 101, 113-118,1984.
Hillier S.G., Afnan M.A., Margara R.A., Winston R.M.L. Ovarian function before in vitro fertilization. J. Endocr. 102, supplement, 81 1984.
Hillier, S.G., Wickings, E.J., Afnan, M., Margara, R.A., Winston, R.M.L. Granulosa cell steroidogenesis before in-vitro fertilization. Biology of Reproduction. 31, 679-686, 1984.
Afnan, M., Hillier, S.G., Winston, R.M.L., Franks, S. Pulsatile gonadotrophin treatment for in-vitro fertilization. Lancet, i, 1239, 1984.
Hillier, S.G., Wickings, J., Afnan, M.A., Margara, R.A. and Winston, R.M.L. Intrafollicular steroids and oocyte function in Gamete Quality and Fertility Regulation, ed Roland R. Excerpta Medica, Amsterdam, 43-52, 1984.
Afnan M.A., Hillier S.G., Winston R.M.L. and Franks S. Pituitary and ovarian response to pulsatile LH-RH given in the mid-follicular phase. J Ster Biochem 20, 6, 1385. 1984.
Hillier S.G., Wickings E.J., Afnan M.A., Margara R.A., Winston R.M.L. Oocyte developmental potential and granulosa cell steroidogenesis in the human ovulatory follicle. Proc. 5th Biennial Workshop, eds R.J. Ryan and D.O. Toft, Ovarian Workshops, Champaign, USA. 1985.
Siddiquey, M., Hillier, S.G., Winston, R.M.L. Fertilization in vitro of cumulus-enclosed oocytes: The effect of timing of the ovulatory hCG injection. Int. J. Fertil., 30, 34-8, 1985
Harlow C, Winston RML, Margara RA, Hillier SG. Steroidogenesis and glycolysis in the developing human ovarian follicle. Hum. Reproduction, 1, 23, 1986.
Harlow CR, Winston RML, Margara RA and Hillier SG. Gonadotrophic control of human granulosa cell glycolysis. Hum. Reprod., 2, 649-653, 1987.
Franks S., Mason H.D., Polson D.W, Winston R.M.L., Margara R.A. and Reed M.J. The mechanism and management of ovulatory failure in women with Polycystic Ovarian Syndrome. Human Reproduction, 3 (4), 531-4, 1988
Fisch B., Winston R.M.L., Hillier S.G. Isolation and characterisation in vitro of steroidogenic cells from the human corpus luteum. J. Endocrinol. 1989; 122, 303-11.
Mason HD; Margara R; Winston RM; Beard RW; Reed MJ; Franks S (1990) Inhibition of oestradiol production by epidermal growth factor in human granulosa cells of normal and polycystic ovaries. Clin Endocrinol 33 (4) 511-7
Mason HD, Margara R, Winston RML, Seppala M, Koistinen R, Franks S (1993) Insulin-like growth factor-I (IGF-I) inhibits production of IGF-binding protein-1 while stimulating estradiol secretion in granulosa cells from normal and polycystic ovaries. J Clin Endocrinol Metab 76, 1275-9
Fisch B, Rose MP, Elder MG, Winston RML, Margara RA, Hillier SG (1994) Effects of oestrogen on progesterone synthesis and arachidonic acid metabolism in human luteal cells. Clin Endocrinol 40, 21-32
Mason HD; Willis DS; Beard RW; Winston RM; Margara R; Franks S (1994) Estradiol production by granulosa cells of normal and polycystic ovaries: relationship to menstrual cycle history and concentrations of gonadotropins and sex steroids in follicular fluid. J Clin Endocrinol Metab 79, 1355-60
Harlow CR, Jenkins JM, Winston RML (1997) Increased follicular fluid total and free cortisol levels during the luteinizing hormone surge. Fertil Steril 68(1):48-53
A, Krausz T, Margara RA, Winston RML (1997) Follicular density in ovarian biopsy of infertile women: a novel method to assess ovarian reserve. Hum Reprod 12, 1028-31
General and miscellaneous:
Naish, F.P., Clark, A., Winston RML, and Peters, D.K.(1973) Serum and urine fibrogen derivatives in normal pregnancy and pre-eclampsia. Obstet. Gynecol. 42:861,.
Winston RML (1974) The relation between size and pathogenicity of Trichomonas vaginalis. J. Obstet. Brit. Comm. 81:399,.
Wigglesworth, J.S., Winston RML and Bartlett, K. (1977) Influence of the central nervous system in fetal lung development. Experimental study. Arch. Dis. Childhood 52:965.
Golan, A., Dargenio R. and Winston, R.M.L. (1984) Experimental endometriosis: A microsurgical animal model in rats. Isr. J. Med. Sci. 20: 1094-6.
Dargenio R., Golan A. and Winston R.M.L. (1984) Experimental endometriosis and fertility: Comparison of effects of an antigonadotrophin (danazol) and an antiprostaglandin (indomethacin). Acta Eur. Fertil. 15: 257-9.
Margara, R.A. and Winston, R.M.L. (1984) Myomectomy. J. Obstet. Gynaecol., 5,1, 33-6.
Golan A, Dargenio R., Winston R.M.L. (1984) Fulguration versus resection of experimental endometrial peritoneal implants in the rat. Aust N.Z. J. Obstet. Gynaecol. 24, 286-88.
Spring J.E. and Winston R.M.L. (1985) Congenital lymphodema and its complications in pregnancy and the puerperium. J. Obstet. Gynaecol. 5: 170-3.
Margara R.A. and Winston R.M.L (1988). The results of treatment of intrauterine synechiae. J. Obstet. Gynaecol. 74-86
Brosens JJ; de Souza NM; Barker FG; Paraschos T; Winston RML (1995) Endovaginal ultrasonography in the diagnosis of adenomyosis uteri: identifying the predictive characteristics. Br J Obstet Gynaecol. 102(6): 471-4
de Souza NM; Brosens JJ; Schwieso JE; Paraschos T; Winston RML (1995) The potential value of magnetic resonance imaging in infertility. Clin Radiol 50, 75-9
Moohan JM; Winston RM; Lindsay KS (1995) The variable effects of 2′-deoxyadenosine mentoxifylline. on human sperm motility and hyperactivation in vitro. Hum Reprod. 10(5): 1098-103
Selected review articles or editorials in peer-review journals.
Winston RML (1989) The management of the infertile patient in general practice. General Practitioner, 2, 1-8.
Perks NF, Winston RML (1991) Ethically acceptable ovum donors Br J Hosp Med 45, 71.
Winston RML (1991) Allocation of resources for infertility treatments. Bailleres Clin Obstet Gynaecol 5, 551-73
Winston RML (1991) Is the Government undermining infertility treatment? Medical Monitor
Winston RML (1992) The selection of IVF or microsurgery. Editorial. J IVF Gen , 9, 309-311.
Winston RML (1993) Diagnosis and Management of Infertility. Drug Ther Bull
Winston RML (1993) Problems of conception in older women. Well Woman Team.
Winston RML (1994) Treating menopausal infertile women. Brit J Hosp Med 47, 88
Winston RML (1997) The promise of cloning for human medicine. Br Med J 314, 913-4.
Simmons S, Winston R (1977) Nurse and consultant. Nursing Times 93(36):28-30
Books and Chapters in Books
Winston RML Obstetric and gynaecological section. In: Modern Surgery for Nurses, Selwyn Taylor(Ed.), Heinemann 9th edition, London, p. 743, 1974.
Winston RML. Foreward and two chapters. In: Microsurgery in Gynaecology, Phillips, A. (Ed.), A.A.G.L., St. Louis, 1977.
Winston RML Tuboplasty. In Operative Gynaecology, 3rd edition, Roberts DWT (Ed), Butterworth London 1977.
Brosens, I. and Winston RML (Editors) Reversibility of Female Sterilization. Academic Press, London, 1978.
Winston RML. Reversal of tubal sterilization. In: Microsurgical Techniques in Infertility Problems. Gomel, V. (Ed.), Clinical Obstetrics and Gynaecology 23(4):1261, 1980.
Winston RML. Reversibilidade da esterilizacao Tubaria. In: Temas de Contracepcao. Salvatore, de Castro, M.P.P., de Carvalho, W.D.P. and Goldsmith, A. (Eds.), Almed, Sao Paulo, pp. 105-110, 1980.
Winston RML, Microsurgical restoration of fertility following tubal ligation in Voluntary Sterilization: a decade of achievement. M.E. Schima and I. Lubell (eds.), New York, Association for Voluntary Sterilization, 131-134, 1980.
Winston RML. Endometrial biopsy. In: Infertility, Philipp, E.E. and Carruthers, G.B. (Eds.), Heinemann, London, 1981, p.79-82.
Winston RML Tubal Microsurgery in Progress in Obstetrics and Gynaecology ed. by Studd, J. Churchill Livingston, London. 1981, 291-393.
Winston RML Microsurgical procedures upon tube and ovary. In: Colour Atlas of Gynaecological Surgery, Vol. 5. Lees, D. and Singer, A. (Eds.), Wolfe Medical, London, p. 130 et. seq. 1981.
Chamberlain, G.V.P. and Winston RML.: Tubal Infertility. Blackwells, London, 1981.
Winston RML Microsurgery of the fallopian tube. In Wallach, E.E. & Kempers, R.D. eds, Modern Trends in Infertility and Conception Control. Harper & Row, Philadelphia, 260-269, 1982.
Winston RML. Reversal of female sterilization. In Current Therapy of Infertility edited by Garcia, C., Mastroianni, L., Amelar, R., and Dubin, L. Decker, New York, 1982, 202-207.
Winston RML. Microsurgical tuboplasty in Gynaecological Microsurgery, edited by A. Fujii, Tokai University Press, Tokyo, 1983, 191- 120.
Winston RML. Microsurgery of the Fallopian Tubes. In Progress in Gynecology, Vol VII edited by M.L. Taymor, Grune & Stratton, Orlando, Florida. 1983, 399-424.
Winston RML. and Margara, R.A. Infertility surgery in the female. In Human Infertility edited by Insler V. and Lunenfeld B., Churchill Livingstone, London., 1986.
Winston RML. Surgical conditions of the Fallopian tube in Operative Gynaecology edited by Te Linde and Mattingly, Lippincott, Boston, 1986.
Winston RML and Darling, M, Infertility for Undergraduates and Postgraduates. Pergamon Press. 1986
Winston RML Microsurgery in Principles of Gynaecological Surgery, ed SL Stanton Springer-Verlag, Berlin 1986.
Winston RML Operations for infertility. In Operative Surgery: Gynaecology and Obstetrics. 4th Edition, ed. J. Monaghan. Butterworths, London, March, 1986.
Winston RML and Margara RA Infertility surgery in the Female. In: Insler V. and Lunenfeld B, eds.Human Infertility. London, Churchill Livingstone, 1986.
Winston RML Tubal Microsurgery: In: Infertility Treatment ed M.Seibl, Grune Stratton, New York, 1988.
Winston RML. Infertility in “Infertility” Update Postgraduate Series ed RML Winston, Reed Healthcare Communications, 1991.
Winston RML Menotropins in Therapeutic Drugs, ed Sir Colin Dollery, Churchill Livingstone, London, 1991
Winston RML The value of in vitro research. In Ethics on the Frontiers of Human Existence, ed Paul Badham, Paragon House, New York, 1991.
Winston RML The Role of Reproductive surgery. In AA Templeton & JO Drife, Infertility, Springer-Verlag, 1992, pp184-198.
Winston RML, Soussis J, Dawson K, Conaghan J, Handyside AH (1992) An overview of preimplantation diagnosis. In Embryo Manipulation ed S Fishel.
Winston RML. Infertility. Overview of recent therapeutic developments. Martin Dunitz, London, 1993.
Winston RML, Handyside AH (1994) Clinical results of preimplantation genetic diagnosis. In Serono Symposia series ed J Cohen, J Grifo, A Handyside.
Professional teaching films and videotapes:
The use of the microscope for salpingostomy. 16mm film. Prize at AFS, Miami, 1977.
Tubocornual anastomosis for inflammatory disease. 16mm film. First shown Madrid, 1978.
Microsurgery for Sterilization Reversal. 16mm film. First shown Seoul, Korea, 1979.
Transplantation of the Human Fallopian Tube. 16mm film. Grenoble, 1981.
Handling fine suture material. Videotape, Leuven, 1982.
Salpingostomy simplified. 16mm film. Bombay, 1983.
Tubocornual Anastomosis. Teaching Videotape sponsored by Winthrop Laboratories, 1985.
Preparation of the Pelvis for IVF. Teaching Videotape sponsored by Winthrop Laboratories, 1985.
Salpingostomy. Teaching Videotape sponsored by Winthrop Laboratories, 1985.
Seven Ways to improve your IVF programme. Videotape sponsored by Winthrop Laboratories, 1985.
Endometriosis. Teaching videotape, Winthrop-Sterling, 1987.
Adhesion prophylaxis. Teaching videptape with London Rubber Company, 1988.
Artificial insemination. Teaching videotape. Organon Laboratories, 1992.
Laparoscopic surgery. Video-programme made for Royal College Obstetricians & Gynaeclogists, 1992.